Biologic Therapy for Nasal Polyps – A New Era in Treatment
For years, patients with chronic nasal polyps have faced recurring symptoms despite repeated courses of steroids or surgery. Now, a new class of medicines called biologic therapies offers long-term relief — and they’re available right here in Hampshire.
At Hampshire ENT clinics, our team works closely with respiratory and allergy specialists to deliver personalised biologic therapy for patients with severe or recurrent nasal polyps.
🧬 What Are Biologic Therapies?
Biologics are targeted antibody treatments that act on specific parts of the immune system driving inflammation.
In chronic rhinosinusitis with nasal polyps (CRSwNP), the inflammation is often due to overactive Type 2 (eosinophilic) inflammation. Biologics help by blocking these inflammatory signals, reducing swelling and polyp size.
💊 Who Can Benefit?
You may be suitable for biologic therapy if you have:
Persistent nasal polyps despite surgery or steroid treatment
A reduced sense of smell or constant nasal blockage
Associated asthma or aspirin sensitivity
Need for repeated courses of oral steroids
Your ENT specialist will assess your symptoms, nasal endoscopy findings, and previous treatments to decide if biologics are appropriate.
💉 Types of Biologic Treatments
Common biologic medicines licensed for nasal polyps include:
Dupilumab (Dupixent®) – targets IL-4 and IL-13 inflammation pathways
Omalizumab (Xolair®) – targets allergic IgE-driven inflammation
Mepolizumab (Nucala®) – targets IL-5, reducing eosinophilic inflammation
These are given as regular injections, often every 2–4 weeks, and can be administered in clinic or at home after training.
🌟 Benefits of Biologic Therapy
Reduces nasal blockage and congestion
Improves sense of smell and quality of life
Reduces or eliminates the need for surgery
Lowers dependence on oral steroids
Improves asthma control in patients with combined airway disease
🤝 Multidisciplinary Care in Hampshire
Our joint ENT/Respiratory biologics clinic brings together specialists in sinus disease, allergy, and severe asthma to provide integrated care for patients with complex airway inflammation.
This collaborative approach ensures patients receive the right biologic therapy for both their nasal and lower airway symptoms.
📍 Accessing Biologic Therapy in Hampshire
If you have persistent or recurrent nasal polyps despite other treatments, biologic therapy may finally offer lasting relief. Clinics available at Portsmouth, Winchester & Salisbury, and the wider Hampshire region.
👉 Contact Hampshire ENT clinics to arrange a consultation and find out if you’re eligible for biologic therapy.